RNF41 reverses liver fibrosis

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Chronic liver disease is characterized by declining hepatic function, caused by chronic inflammation or insult to the liver resulting in progressive deposition of fibrous tissue. There are currently no curative therapies except for organ transplantation, which requires lifelong immunosuppression.

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Nature Reviews Drug Discovery 22, 697 (2023)

doi: https://doi.org/10.1038/d41573-023-00125-6

Moreno-Lanceta, A. et al. RNF41 orchestrates macrophage-driven fibrosis resolution and hepatic regeneration. Sci. Transl Med. 15, eabq6225 (2023)

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